S?çanlarda Bupropion ve Vareniklinin Morfin Yoksunlu?u Sendromu Üzerine Etkileri

Objective: Opioid dependence is a chronic and complex disorder characterized by relapse remission. Chronic administration of morphine causes symptoms physical psychological dependence. The purpose the present study was to investigate effect anti-addictive drugs such as bupropion varenicline on naloxone precipitated withdrawal syndrome in rat model. Materials Methods: To assess morphine, Wistar albino rats were intraperitoneal (i.p.) administered increasing doses twice daily for 5 days, 4 hours after single dose day 6, 15 minutes before subcutaneous (s.c.) (2 mg/kg, s.c.) elicit symptoms. Physical evaluated giving (5, 10 20 i.p.) (0.5. 1 2 s.c) minutes. Results: morphine-dependent had significantly more than naive control rats. results demonstrated during induction attenuated most severity Co-administration reduced jumping, wet dog shaking, weight loss total found be effective bupropion, but no loss. Conclusion: These outcomes provide preliminary data that could used candidate attenuate